In-Depth Analysis of the N-Glycome of Colorectal Cancer Cell Lines
Wang D, Kuzyk V, Madunić K, Zhang T, Mayboroda OA, Wuhrer M, Lageveen-Kammeijer GSM.
Int. J. Mol. Sci. 2023, 24(5), 4842; DOI:10.3390/ijms24054842
Sialyl LewisX/A and Cytokeratin Crosstalk in Triple Negative Breast Cancer
Carlota Pascoal, Mylène A. Carrascal, Daniela F. Barreira, Rita A. Lourenço, Pedro Granjo, Ana R. Grosso, Paula Borralho, Sofia Braga & Paula A. Videira
Cancers 2023, 15(3), 731
(2023) DOI:10.3390/cancers15030731
O-glycomic and proteomic signatures of spontaneous and butyrate-stimulated colorectal cancer cell line differentiation
Madunić K, Luijkx YMCA, Mayboroda OA, Janssen GMC, van Veelen PA, Strijbis K, Wennekes T. Lageveen-Kammeijer GSM & Wuhrer M.
Molecular & Cellular Proteomics
(2023) DOI:10.1016/j.mcpro.2023.100501
A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy
Patrício RPS, Videira PA, Pereira F.
Bioorganic & Medicinal Chemistry
(2022) DOI:10.1016/j.bmc.2021.116530
Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation
Wang D, Zhang T, Madunić K, de Waard AA, Blöchl C, Mayboroda OA, Griffioen M, Spaapen RM, Huber CG, Lageveen-Kammeijer GSM and Wuhrer M.
J Proteome Res
(2022) DOI: https://doi.org/10.1021/acs.jproteome.1c00911
A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS
Kotsias M, Madunić K, Nicolardi S, Kozak RP, Gardner RA, Jansen BC, Spencer DIR, Wuhrer M.
Glycoconjugate Journal
(2021) DOI: 10.1007/s10719-021-10003-1
Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode.
Madunić K, Wagt S, Zhang T, Wuhrer M, Lageveen-Kammeijer GSM.
Analytical Chemistry
(2021) DOI: 10.1021/acs.analchem.1c00023
Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2)
Pirro M, Mohammed Y, de Ru AH, Janssen GMC, Tjokrodirijo RTN, Madunić K, Wuhrer M, van Veelen PA, Hensbergen PJ
International Journal of Molecular Sciences
(2021) DOI: 10.3390/ijms22105369
Site-Specific N-Linked Glycosylation Analysis of Human Carcinoembryonic Antigen by Sheathless Capillary Electrophoresis–Tandem Mass Spectrometry
Pont L, Kuzyk V, Benavente F, Sanz-Nebot V, Mayboroda OA, Wuhrer M, Lageveen-Kammeijer GSM
Journal of Proteome Research
(2021) Journal of Proteome Research DOI: https://doi.org/10.1021/acs.jproteome.0c00875
Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode
Madunić K, Wagt S, Zhang T, Wuhrer M, Lageveen-Kammeijer GSM.
Analytical Chemistry
(2021) Analytical Chemistry DOI: https://doi.org/10.1021/acs.analchem.1c00023
Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer
Lenneke A. M. Cornelissen, Athanasios Blanas†, Anouk Zaal†, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk and Sandra J. van Vliet
Frontiers in Oncology
(2020) DOI: https://doi.org/10.3389/fonc.2020.01622
N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity
Pirro M, Mohammed Y, van Vliet SJ, Rombouts Y, Sciacca A, de Ru AH, Janssen GMC, Tjokrodirijo RTN, Wuhrer M, van Veelen, PA, Hensbergen PJ.
(2020) International Journal of Molecular Sciences DOI: 10.3390/ijms21155522
O- and N-glycosylation analysis of cell lines by ultrahigh resolution MALDI-FTICR-MS
Vreeker GCM, Nicolardi S, Madunić K, Kotsias M, van der Burgt YEM, Wuhrer M.
(2020) International Journal of Mass Spectrometry DOI: 10.1016/j.ijms.2019.116267
Simultaneous Immunoglobulin A and G Glycopeptide Profiling for High-Throughput Applications
Momčilović A, de Haan N, Hipgrave Ederveen AL, Bondt A, Koeleman CAM, Falck D, de Neef LA, Mesker W, Tollenaar RAEM, de Ru AH, van Veelen PA, Wuhrer M, Dotz V.
Analytical Chemistry
(2020) DOI 10.1021/acs.analchem.9b05722
Site-Specific N-Linked Glycosylation Analysis of Human Carcinoembryonic Antigen by Sheathless Capillary Electrophoresis-Tandem Mass Spectrometry
Pont L, Kuzyk V, Kuzyk V, Benavente F, Sanz-Nebot V, Mayboroda OA, Wuhrer M, Lageveen-Kammeijer, GSM.
(2020) Journal of Proteome Research DOI: 10.1021/acs.jproteome.0c00875
The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition
Pucci M, Ferreira IG, Malagolini N, Ferracin M, Dall’Olio F.
(2020) DOI: 10.3390/ijms21186558
A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases.
Ruprecht C, Bartetzko MP; Senf D, Lakhina A, Smith PJ, Soto MJ, Oh H, Yang J, Chapla D, Varón Silva D, Clausen MH, Hahn MG, Moremen KW, Urbanowicz BR, Pfrengle F.
(2020) Angewandte Chemie DOI: 10.1002/ange.202003105
Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines
Pirro M, Rombouts Y, Stella A, Neyrolles O, Burlet-Schiltz O, van Vliet SJ, de Ru AH, Mohammed Y, Wuhrer M, van Veelen PA, Hensbergen PJ.
(2020) Biochimica et Biophysica Acta (2020) DOI 10.1016/j.bbagen.2020.129513
MHC Class I Stability is Modulated by Cell Surface Sialylation in Human Dendritic Cells
Silva Z, Ferro , Almeida D, Soares H, Ferreira JA, Deschepper FM, Hensbergen PJ, Pirro M, van Vliet SJ, Springer S, Videir PA.
Pharmaceutics
(2020) DOI: 10.3390/pharmaceutics12030249
Colorectal cancer cell lines show striking diversity of their O- glycome reflecting the cellular differentiation phenotype
Madunić K, Zhang T, Mayboroda OA, Holst S, Stavenhagen K, Jin C, Karlsson NG, Lageveen-Kammeijer GM, Wuhrer M.
Cellular and Molecular Life Sciences
(2020) DOI: 10.1007/s00018-020-03504-z
Colon-specific immune microenvironment regulates cancer progression versus rejection
Trimaglio G, Tilkin-Mariamé A, Feliu V, Lauzeral-Vizcaino F, Tosolini M, Valle C, Ayyoub M, Neyrolles O, Vergnolle N, Rombouts Y, Devaud C.
OncoImmunology
(2020) DOI: 10.1101/2020.01.02.892711
L1CAM as an E-selectin Ligand in Colon Cancer
Deschepper FM, Zoppi R, Pirro M, Hensbergen PJ, Dall’Olio F, Kotsias M, Gardner RA, Spencer DIR, Videira PA.
International Journal of Molecular Sciences
(2020) DOI: 10.3390/ijms21218286
A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases
Ruprecht C, Bartetzko MP, Senf D, Lakhina A, Smith PJ, Soto MJ, Oh H, Yang J, Chapla D, Silva DV, Clausen HV, Hahn MG, Moremen KW, Urbanowicz BR, Pfrengle F.
Angewandte Chemie
(2020) Angewandte Chemie DOI: https://doi.org/10.1002/ange.202003105
High Expression of the Sda Synthase B4GALNT2 Associates with Good Prognosis and Attenuates Stemness in Colon Cancer
Pucci M, Ferreira IG, Orlandani M, Malagolini N, Ferracin M , Dall’Olio F.
(2020) DOI: https://doi.org/10.3390/cells9040948
Development of a 96-well plate sample preparation method for integrated N- and O-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry
Zhang T, Madunić K, Holst S, Zhang J, Jin C, ten Dijke P, Karlsson NG, Stavenhagen K Wuhrer A.
(2020) DOI: https://doi.org/10.1039/C9MO00180H
FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State
Blanas A, Zaal A, van der Haar Àvila I, Kempers M, Kruijssen L, de Kok M, Popovic MA, van der Horst JC and van Vliet SJ.
(2020) DOI: https://doi.org/10.3390/cancers12092580
The Role of Glycosphingolipids in Immune Cell Functions.
Zhang T, de Waard, A.A, Wuhrer M, Spaapen R.M.
(2019) DOI: 10.3389/fimmu.2019.00090
Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis.
Kotsias M, Blanas A, van Vliet SJ, Pirro M, Spencer DIR, Kozak RP.
(2019) Plos One 10.1371/journal.pone.0223270
Improved and semi-automated reductive β-elimination workflow for higher throughput protein O-glycosylation analysis.
Kotsias M, Kozak RP, Gardner RA, Wuhrer M, Spencer DIR.
PLoS ONE
(2019) DOI: 10.1371/journal.pone.0210759
Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots
Simunovic J, Vilaj M, Trbojevic-Akmacic I, Momcilovic A, Vuckovic F, Gudelj I, Juric J, Nakic N, Lauc G, Pezer M.
(2019) DOI: https://doi.org/10.1093/glycob/cwz061
OGT Controls the Expression and the Glycosylation of E‐cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines
Biwi J, Clarisse C, Biot C, Kozak RP, Madunic K, Mortuaire M, Wuhrer M, Spencer DIR, Schulz C, Guerardel Y, Lefebvre T, Vercoutter‐Edouart A.
(2019) DOI: https://doi.org/10.1002/pmic.201800452
Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types
Venturi G, Ferreira IG, Pucci M, Ferracin M, Malagolini N, Chiricolo M, Dall’Olio F.
(2019) DOI: 10.1093/glycob/cwz053
Serum protein N-glycosylation changes in multiple myeloma
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S.
(2019) Biochim Biophys Acta Gen Subj. 1863(5):960-970. DOI: 10.1016/j.bbagen.2019.03.001.
The Many Ways by Which O -GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations.
Biwi J, Biot C, Guerardel Y, Vercoutter-Edouart A, Lefebvre T.
(2018) DOI: 10.3390/molecules23112858
Serum sialylation changes in cancer
Zhang Z, Wuhrer M, Holst S.
(2018) Glycoconjugate Journal DOI: 10.1007/s10719-018-9820-0 http://europepmc.org/articles/PMC5916985
Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis.
Cornelissen LAM, Blanas A, van der Horst JC, Kruijssen L, Zaal A, O’Toole T, Wiercx L, van Kooyk Y, van Vliet SJ.
(2018) Int J Cancer. DOI: 10.1002/ijc.32084
Glycoproteomic analysis of MGL binding proteins on acute T cell leukemia cells.
Pirro M, Schoof E, van Vliet SJ, Rombouts Y, Stella A, de Ru A, Mohammed Y, Wuhrer M, van Veelen PA, Hensbergen PJ.
(2018) J Proteome Res. DOI: 10.1021/acs.jproteome.8b00796
Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells
Blanas A, Cornelissen LAM, Kotsias M, van der Horst JC, van de Vrugt HJ, Kalay H, Spencer DIR, Kozak RP, van Vliet SJ.
(2018) Glycobiology 29: 137–150. DOI: 10.1093/glycob/cwy096
The association between subclass-specific IgG Fc N-glycosylation profile and hypertension in the Uygur, Kazak, Kirgiz and Tajik populations
(2018) Liu JN, Dolikun M, Štambuk J, Trbojević-Akmačić I, Zhang J, Wang H, Zheng DQ, Zhang XY, Peng HL, Zhao ZY, Liu D, Sun Y, Sun Q, Li QH, Zhang JX, Sun M, Cao WJ, Momčilović A, Razdorov G, Wu LJ, Russell A, Wang YX, Song MS, Lauc G, Wang W.
J Hum Hypertens 32:555. DOI: 10.1038/s41371-018-0071-0
Fucosylated antigens in cancer: an alliance toward tumor progression, metastasis and resistance to chemotherapy
Blanas A, Sahasrabudhe NM, Rodríguez E, van Kooyk Y, van Vliet SJ.
(2018) Frontiers in Oncology 8:39. DOI: 10.3389/fonc.2018.00039
Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling
Ferreira IG, Pucci M, Venturi G, Malagolini N, Chiricolo M, Dall’Olio F.
(2018) International Journal of Molecular Sciences 19 pii: E580. DOI: 10.3390/ijms19020580
Plasma N-glycome composition associates with chronic low back pain
Trbojević-Akmačić I, Vučković F. Vilaj M, Skelin A, Karssen LC, Krištić J, Jurić J, Momčilović A, Šimunović J, Mangino M, De Gregori M, Marchesi M , Dagostino C, Štambuk J, Novokmet M, Rauck R, Aulchenko YS, Primorac D, Kapural L, Buyse K, Mesotten D, Williams FMK, van Zundert J, Allegri M, Lauc G.
(2018) Biochimica et Biophysica Acta (BBA) – General Subjects 1862: 2124. DOI: 10.1016/j.bbagen.2018.07.003
Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue
Carrascal M, Talina C, Borralho P, Mineiro A, Henriques A, Pen C, Martins M, Braga S, Sackstein R, Videira P.
(2018) BMC Cancer 18:495. DOI:10.1186/s12885-018-4410-x
Immunoglobulin G Glycome in colorectal cancer
Vučković F, Theodoratou E, Thaçi K, Timofeeva M, Vojta A, Štambuk J, Pučić-Baković M, Rudd P, Đerek L, Servis D, Wennerström A, Farrington SM, Perola M, Aulchenko Y, Dunlop M, Campbell H, Lauc G
(2016) Clinical Cancer Research, 22(12):3078-3086. DOI: 10.1158/1078-0432.CCR-15-1867
Mechanisms of disease: The human N-glycome
Lauc G, Pezer M, Rudan I, Campbell H
(2016) BBA Gen Subjects, 1860:1574–1582, DOI:10.1016/j.bbagen.2015.10.016
Histo-blood group glycans in the context of personalized medicine
Dotz V, Wuhrer M
(2016) BBA Gen Subjects, 1860:1596-1607. DOI: 10.1016/j.bbagen.2015.12.026
For Open-access version on arXiv click here.